Bell's girls, led by fifth-grader Kelly Brown, eighth-grader Caitlin Gibson and senior Brooke White, stormed out to an early lead never looked back.
Brown was ahead by over 100 yards before the first quarter-mile was run and won the 5k run by 38 seconds over Gibson.
Brown posted a time of 21:37.03 on her home course, which includes an uphill climb into the woods behind Bell Central.
Gibson and White placed second and third, while teammates Sarah Hobbs and Brittany Collins were fourth and fifth.
The top seven finishers make the all-SEKC team. The five Lady Cats were joined by Williamsburg's Sarah Perkins, who finished fourth and Evarts eighth-grader Haley Helton.
Brittany Rutherford placed ninth for Bell County.
With their top five runners accumulating 17 points, the Lady Cats easily won the team competition. Williamsburg was second with 55 points, just ahead of Knox Central's 56.
In the boys' race, Middlesboro's Travis Faulkner broke away from the field at the start of the race, but Bell's James Brown and Harlan's Zach Lawrence caught up to him inside the first quarter-mile.
Meanwhile Knox Central's Chris Ward was staying back in the pack, waiting to make his move.
Ward, a senior, overtook Brown, a seventh-grader, to win the race with a time of 17:49.77. Brown held on for second, just four seconds behind.
Faulkner, a sophomore, faded after his fast start and finished 16th with a time of 21:02.69. Nick Smith led the Middlesboro runners with a time of 20:22.17, good for 11th place.
Williamsburg's Raymond Surber was third, nearly a minute behind Brown and Lawrence held on for fourth.
Knox Central runners Nathan Broughton, Colby Faulkner, and Cody Swafford rounded out the top seven for all-SEKC honors.
Senior Adam Hensley ran a 20:43.40 for Bell to finish 13th with teammate Scott Lee next, about nine and a half seconds behind.
Matthew Elliott was 17th, Adam Overbay 19th and Cody Saylor 23rd for Bell. The Bobcats' team score of 59 was good for second place, just ahead of Harlan's 62. Knox Central was first with 27 points.